Building Muscle on Keto: An Evidence-Based Guide
9 min read

Building Muscle on Keto: An Evidence-Based Guide

contributor
Updated Dec 9, 2019
Brady Holmer
keto-dietketosistraining

Keto is a weight loss diet...but it doesn’t have to be.

Even though thousands of user testimonials and dozens of research studies have solidified the effectiveness of the ketogenic diet to promote and sustain weight and fat loss, this diet has many more applications than slimming down.

One of those applications is for athletes and individuals who want to get leaner, stronger, and even pack on muscle. However, there is a common myth floating around that the ketogenic diet—which isn’t necessarily a “high protein diet”—makes it hard, if not impossible, to gain muscle.

What’s the source of this belief, and does the criticism hold water? Should bodybuilders be adopting keto?

This article will help to clear the air on the keto diet as it relates to muscle building and dispel some common misheld beliefs along the way. We want to make the case (backed by evidence) that you can maintain and even build muscle mass while adhering to a strict ketogenic diet.

But first, let’s cover some of the basics on how to muscle is built.

Muscle Protein Synthesis 101

Muscle protein synthesis (MPS) is the process that our body uses to build new proteins; it’s essential if we want to gain muscle mass or make our muscles larger—a process known as muscle hypertrophy.

There are a few biochemical pathways that govern protein synthesis. These anabolic (growth-promoting) pathways are activated by things like nutrients from food and, perhaps most importantly, exercise. The exercise has to be specific though.

Overloading the muscle using resistance exercise is essential to increase muscle protein synthesis and ultimately, size and strength.

So, to “get big” you have to “lift big” through weight training. But how exactly does weightlifting increase the size of muscles?

mTOR and Muscle Building

Interest in the mammalian target of rapamycin (mTOR) is growing in the area of longevity. However, this cellular sensor is also involved in the process of muscle hypertrophy and protein synthesis.

mTOR is a nutrient sensor—meaning that it can sense whether the body is in a “fed” or “fasted” state.

mTOR can also sense mechanical forces. This is where its involvement in hypertrophy comes from. When we overload a muscle by lifting heavy weights, mTOR is activated.1,2 Activation of mTOR has two functions—stimulating muscle protein synthesis and preventing protein breakdown. This has a dual effect on helping to increase muscle mass.

Interestingly, the more you activate mTOR, the more you are able to increase muscle growth and strength.3,4 It’s a dose-response effect.

mTOR can also be activated by hormones in the body known as growth factors. These include insulin and insulin-like growth factor—both of which activate mTOR and lead to an increase in muscle protein synthesis.1

Amino Acids are Essential

All proteins (in the body and in food) are made up of amino acids. That’s why they’re often referred to as the “building blocks” of proteins. Without amino acids, we couldn’t build muscle.

Especially important to the growth and maintenance of muscle mass are the branched-chain amino acids (BCAAs).

These amino acids are also known as Essential amino acids, meaning that we must consume them in our diet because they’re not produced in the body.

Ingestion of BCAAs, especially the BCAA leucine, stimulates muscle protein synthesis through mTOR and other processes.5,6,7 Studies have shown that the BCAAs in particular are the most effective at causing muscle hypertrophy and preventing muscle breakdown, even more effective than the growth-factor insulin.8,9

Amino acids are the reason for the recommendation to consume protein after a hard workout; since this will maximally stimulate muscle protein synthesis and help you recover from your effort. While overall protein balance may be more important for muscle protein synthesis, some data show that consuming 20 - 30 grams of high-quality protein after exercise will maximally stimulate protein synthesis. Make sure to include at least 2 grams of leucine—the most potent driver of protein synthesis.

Do You Need Carbs to Build Muscle?

Given it's advocacy of extremely low carblow intake, the keto diet has been advised against by many in the bodybuilding and sports performance world. The idea that carbohydrates are necessary to induce muscle growth probably came from the fact that insulin and IGF-1, which both rise in response to carbohydrate intake, also stimulate muscle protein synthesis.

Furthermore, many recommendations exist that tell athletes to consume protein plus carbohydrates in the post-workout window to really maximize gains and promote recovery. Again, the thought is that the carbohydrates will stimulate insulin, promoting a greater amount of muscle protein synthesis than protein alone.

However, when studies compare protein ingestion alone to a combination of protein and carbs after resistance exercise, there is no difference in muscle protein synthesis.10,11,12,13 Long story short: the carbs don’t seem to be adding anything extra.This is probably due to the fact that the amount of protein ingested is enough to raise insulin levels and activate mTOR. More insulin doesn’t necessarily mean more protein synthesis, in this case.10,11

This might silence any argument against using the keto diet to build muscle. But another argument against keto for athletes has to do with glycogen (stored glucose) in muscle.

If glycogen stores are low during exercise, this could compromise energy availability and limit performance. Not something that any athlete wants. However, this may be more of a concern for athletes involved in endurance activities where glycogen depletion becomes an issue. Athletes in sports involving heavy lifts or bodybuilding might not experience negative effects from low glycogen.

However, the data don’t support that glycogen levels are reduced on a ketogenic diet—at least after a sufficient period of adaptation occurs.

In fact, keto-adapted athletes who were compared to athletes consuming around 600 grams of carbohydrates per day actually had similar levels of stored muscle glycogen. After exercise, the keto-adapted athletes were also able to replenish their levels of stored glycogen just as well as the carbohydrate-consuming athletes—despite consuming about 75% less carbohydrates during that period.14 Something happens to keto-adapted athletes that allow them to maintain glycogen levels at a high level. But what?

Maintenance of glucose and glycogen levels in the body in the absence of carbohydrate consumption can occur through a process known as gluconeogenesis, or GNG for short. GNG is a process that our body uses to create glucose out of non-carbohydrate sources—mainly amino acids and glycerol from fatty acids.

By “manufacturing” glucose from these other substrates, low-carb athletes are able to replenish and maintain muscle glycogen at similar levels to carb-consuming athletes.

So, the fact that carbs aren’t needed to build muscle or to keep up a sufficient amount of glucose and glycogen to fuel athletic activity is a nail in the coffin against the keto diet for athletes looking to get bigger, stronger, or perform longer.

But we are primarily interested in muscle growth for this article. While the foundation is sound, what does the evidence actually say about building muscle on a ketogenic diet?

A man lifting weights on a bench press, showing what's required for muscle protein synthesis

How Keto Helps You Build Muscle

Where did the idea that you can’t build muscle on keto come from?

For one, there is the idea that low-carbohydrate diets will fail to sufficiently stimulate insulin/IGF-1 in response to training and therefore, impair your ability to grow muscle or even cause muscle loss. Some people think that if you don’t consume carbs alongside your protein, you won’t maximize muscle protein synthesis.

The second and perhaps most cited reason is that the ketogenic diet is one in which protein is moderated—keto doesn’t encourage a super high intake of protein; keeping it around 10 - 15% of total calories. The theory goes that, since protein is essential for growing large muscles, restricting your intake might lead to a significant loss of muscle tissue or an inability to get bigger.

As we will see, the data don’t really support either of these takes.

This is a generally new area of research, so we don’t have a ton of studies. However, some research has been done that points to a net benefit of the keto diet on markers of muscle growth and maintenance.

Get Lean on Keto

Building muscle is great, but another goal of many strength-based athletes is to optimize body composition. A low-carb high-fat diet can do this. Research has shown that athletes who adopt a keto diet experience greater body fat loss than a group of high-carb dieters.15,16 After 8 weeks of a keto-diet and resistance training program, young men experienced reductions in fat mass and visceral adipose tissue—changes that weren’t seen in the non-keto groups.17

It makes sense that fat mass would drop and body fat % go down on a keto diet once you "learn" to efficiently burn fat for energy.

Being keto adapted ultimately leads to a greater ability to utilize fat from food and body storage areas.

As long as lean mass is maintained (which most studies show is the case), increased fat burning capacity will result in improved body composition—less fat and more lean muscle.

Keto Prevents Protein Breakdown

Fail to eat enough protein, the saying goes, and you’ll shrivel up, lose muscle, and go frail.This fear is instilled by people who say that keto doesn’t contain enough protein to maintain lean muscle mass.

However, research shows exactly the opposite—that the ketogenic diet actually prevents muscle from being broken down. When an equal number of calories are consumed on diets containing the same amount of protein but differing levels of carbs, the lower-carb diets actually maintain lean muscle mass to the greatest extent.18

Ketosis might actually improve our ability to utilize proteins. This could be due to the fact that the body no longer needs to breakdown protein for gluconeogenesis—instead utilizing ketones, sparing the protein we have. Studies support this. During ketosis and infusion of ketone bodies, it is shown that the utilization of BCAAs for energy is reduced, leading to enhanced protein synthesis and muscle maintenance.19,20

Not only do ketones spare protein for muscle maintenance, but they actually can significantly increase muscle protein synthesis. Athletes who ingested a ketone supplement made of a BHB monoester had increased activity of mTOR, leading to a doubling of protein synthesis.21

Ketosis seems to have some profound effects of various markers of protein synthesis within the muscle. But how do athletes on a ketogenic diet respond to training. Do the studies show that muscle mass can improve?

The perfect macronutrient calculator for keto

Maintaining balanced macronutrients is a challenge. Subscribe, and we'll send you our easy-to-use macronutrient calculator to track all your food.

Keto Diets and Muscle Building

As the ketogenic diet has risen in popularity with athletes, more researchers are becoming interested in testing the efficacy of this diet for performance.

Let’s see how the keto diet performs.

In one study, a low-carb diet was compared to a traditional western diet during a 10-week resistance training intervention in healthy young males. After 10 weeks, the group on the low-carb diet diet group gained 2.4% lean body mass and reduced their fat mass by 2.2 kilograms, changes which were similar to the group eating a normal diet.22 However, the keto diet actually led to a greater increase in testosterone throughout the study. This study suggests that when combined with strength training, a keto diet is perfectly adequate for increasing body weight, most of which is lean muscle.

The keto diet has also been shown to preserve muscle mass during training—dispelling the myth that keto will cause you to lose muscle.

Two studies provide evidence for this. In the first, a group of elite gymnasts adopted a ketogenic diet while maintaining their training routines. By the end of the study, muscle mass was the same, but they actually got leaner—reducing body fat and body fat percentage significantly.23

Another study provided similar evidence. After 6 weeks on a ketogenic diet, athletes in a CrossFit program experienced no significant change in muscle mass, but significantly reduced their weight, percent body fat, and fat mass.24

It is important to note that in both of these studies, performance was also maintained in the keto diet groups. Keto diets are often advised against due to their potential impact on high-intensity performance measures which require a high glycolytic capacity.

But, sticking to muscle-related outcomes; a bulk of the research indicates that a keto diet in combination with a resistance training program can preserve or increase lean muscle mass, reduce body fat and body fat %, and maintain strength and power.

It will be exciting to see future studies done analyzing the potential for the keto diet to help with muscle building.

A woman doing kettle bell exercises, showing how keto can help grow muscle

Don’t Fear Protein

While carbs are the major macronutrient of interest on keto, protein is another. While the keto diet isn’t necessarily a high-protein diet, it doesn’t necessarily have to be a low-protein one either. In fact, the actual definition of keto includes a “moderate protein” designation.

If we put some numbers to it, even if you’re eating 15% of your calories from protein on a ketogenic diet, a 2,500 calorie per day diet means you’re still getting 93 grams of protein per day. While hard-core lfters will say this value might be too low, it’s still a fairly large amount of protein.

Consuming even higher amounts of protein in the range of 20 - 25% of total calories is even possible on keto.

In some people, they can still get into ketosis without really restricting protein.

This might be especially true for high-activity athletes.

However, there is the possibility that excess protein will kick you out of ketosis due to gluconeogenesis. This is a highly debated topic, however, and many studies have actually failed to find evidence that protein intake increases GNG enough to stop ketogenesis. GNG occurs slowly, and glucose production following a meal is largely independent of protein content or breakdown.25 One study showed that, even under “optimal gluconeogenic conditions”, eating protein failed to increase GNG.26

Individual variability likely exists in the effect of differing levels of protein on a ketogenic diet. However, eating a bit more protein on a keto diet is likely nothing to be fearful of, and even something to consider if you want to build muscle.

See Those Gains

We hope this article has busted the myth that you can’t build muscle on a ketogenic diet. Research studies consistently show increased, if not maintained, levels of muscle mass in groups who undergo training while on a ketogenic diet.

As long as you're dieting right and getting adequate fat intake (mainly healthy fats) as a source of energy, you should be able to successfully get into a state of ketosis while also putting on the muscle you want. Whether your goal is lifting heavier, muscle gain, or bulking, you can accomplish it with a well-planned ketogenic diet.

Anecdotal evidence, while not scientific per se, is powerful too. It isn’t difficult to find dozens, if not hundreds of people on social media who are successfully leaning out and building muscle while eating a ketogenic diet. The “evidence” speaks for itself.

Keto workout guide

Subscribe for our guide of the best workouts to compliment your keto diet.

Scientific Citations

1.Yoon, M. S. (2017). mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass. Front Physiol, 8, 788.
2.Sandri, M., Barberi, L., Bijlsma, A. Y., Blaauw, B., Dyar, K. A., Milan, G, Schiaffino, S. (2013). Signalling pathways regulating muscle mass in ageing skeletal muscle: the role of the IGF1-Akt-mTOR-FoxO pathway. Biogerontology, 14(3), 303-323.
3.Schoenfeld, B. J. (2010). The mechanisms of muscle hypertrophy and their application to resistance training. J Strength Cond Res, 24(10), 2857-2872.
4.Terzis, G., Georgiadis, G., Stratakos, G., Vogiatzis, I., Kavouras, S., Manta, P., Blomstrand, E. (2008). Resistance exercise-induced increase in muscle mass correlates with p70S6 kinase phosphorylation in human subjects. Eur J Appl Physiol, 102(2), 145-152.
5.Fujita, S., & Volpi, E. (2006). Amino acids and muscle loss with aging. J Nutr, 136(1 Suppl), 277s-280s.
6.Atherton, P. J., & Smith, K. (2012). Muscle protein synthesis in response to nutrition and exercise. J Physiol, 590(5), 1049-1057.
7.Fujita, S., Dreyer, H. C., Drummond, M. J., Glynn, E. L., Cadenas, J. G., Yoshizawa, F., Rasmussen, B. B. (2007). Nutrient signalling in the regulation of human muscle protein synthesis. J Physiol, 582(Pt 2), 813-823.
8.Shimomura, Y., Inaguma, A., Watanabe, S., Yamamoto, Y., Muramatsu, Y., Bajotto, G., Mawatari, K. (2010). Branched-chain amino acid supplementation before squat exercise and delayed-onset muscle soreness. Int J Sport Nutr Exerc Metab, 20(3), 236-244.
9.Duan, Y., Li, F., Liu, H., Li, Y., Liu, Y., Kong, X., Yin, Y. (2015). Nutritional and regulatory roles of leucine in muscle growth and fat reduction. Front Biosci (Landmark Ed), 20, 796-813.
10.Staples, A. W., Burd, N. A., West, D. W., Currie, K. D., Atherton, P. J., Moore, D. R., Phillips, S. M. (2011). Carbohydrate does not augment exercise-induced protein accretion versus protein alone. Med Sci Sports Exerc, 43(7), 1154-1161.
11.Koopman, R., Beelen, M., Stellingwerff, T., Pennings, B., Saris, W. H., Kies, A. K., van Loon, L. J. (2007). Coingestion of carbohydrate with protein does not further augment postexercise muscle protein synthesis. Am J Physiol Endocrinol Metab, 293(3), E833-842.
12.Miller, S. L., Tipton, K. D., Chinkes, D. L., Wolf, S. E., & Wolfe, R. R. (2003). Independent and combined effects of amino acids and glucose after resistance exercise. Med Sci Sports Exerc, 35(3), 449-455.
13.Glynn, E. L., Fry, C. S., Timmerman, K. L., Drummond, M. J., Volpi, E., & Rasmussen, B. B. (2013). Addition of carbohydrate or alanine to an essential amino acid mixture does not enhance human skeletal muscle protein anabolism. J Nutr, 143(3), 307-314.
14.Volek, J.S., Freidenreich, D.J., Saenz, C., Kunces, L.J., Creighton, B.C., Bartley, J.M., Davitt, P.M., Munoz, C.X., Anderson, J.M., Maresh, C.M., et al. (2016). Metabolic characteristics of keto-adapted ultra-endurance runners. Metabolism 65, 100-110.
15.Mcswiney, F. T., Wardrop, B., Hyde, P. N., Lafountain, R. A., Volek, J. S., & Doyle, L. (2017). Keto-adaptation enhances exercise performance and body composition responses to training in endurance athletes. Metabolism. doi:10.1016/j.metabol.2017.11.016
16.Caryn Zinn, Matthew Wood, Mikki Williden, Simon Chatterton, and Ed Maunder.
17.Vargas S, Romance R, Petro JL, et al. Efficacy of ketogenic diet on body composition during resistance training in trained men: a randomized controlled trial. J Int Soc Sports Nutr. 2018;15(1):31.
18.Young, C. M., Scanlan, S. S., Im, H. S., & Lutwak, L. (1971). Effect of body composition and other parameters in obese young men of carbohydrate level of reduction diet. Am J Clin Nutr, 24(3), 290-296.
19.Volek, J.S., and Phinney, S.D. (2012). The Art and Science of Low Carbohydrate Performance. (Beyond Obesity LLC ).
20.Nair, K. S., Welle, S. L., Halliday, D., & Campbell, R. G. (1988). Effect of beta-hydroxybutyrate on whole-body leucine kinetics and fractional mixed skeletal muscle protein synthesis in humans. J Clin Invest, 82(1), 198-205.
21.Vandoorne, T., De Smet, S., Ramaekers, M., Van Thienen, R., De Bock, K., Clarke, K., and Hespel, P. (2017). Intake of a Ketone Ester Drink during Recovery from Exercise Promotes mTORC1 Signaling but Not Glycogen Resynthesis in Human Muscle. Front. Physiol. 8, 310.
22.Wilson, J. M., Lowery, R. P., Roberts, M. D., Sharp, M. H., Joy, J. M., Shields, K. A., . . . D'Agostino, D. (2017). The Effects of Ketogenic Dieting
23.Paoli, A., Grimaldi, K., D'Agostino, D., Cenci, L., Moro, T., Bianco, A., and Palma, A. (2012). Ketogenic diet does not affect strength performance in elite artistic gymnasts. J Int Soc Sports Nutr 9, 34.
24.Gregory, R.M., Hamdan, H., Torisky, D.M., Akers, J.D. (2017). A low-carbohydrate ketogenic diet combined with 6-weeks of Crossfit training improves body composition and performance. Int J Sports Exerc Med, 3(2):1-10.
25.Conn JW, Newburgh LH. THE GLYCEMIC RESPONSE TO ISOGLUCOGENIC QUANTITIES OF PROTEIN AND CARBOHYDRATE. J Clin Invest. 1936;15(6):665-71.
26.Fromentin C, Tomé D, Nau F, et al. Dietary proteins contribute little to glucose production, even under optimal gluconeogenic conditions in healthy humans. Diabetes. 2013;62(5):1435-42.
Editor's Choice
Emails worth reading.

Once a week, we'll send you the most compelling research, stories and updates from the world of human enhancement.

H.V.M.N. Co-founders Michael Brandt and Geoffrey Woo

These statements have not been evaluated by the FDA. Our products are not intended to diagnose, treat, cure, or prevent any disease.

© 2020 HVMN Inc. All Rights Reserved. H.V.M.N.®, Health Via Modern Nutrition™, Nootrobox®, Rise™, Sprint®, Yawn®, Kado™, and GO Cubes® are registered trademarks of HVMN Inc. ΔG® is a trademark of TΔS® and used under exclusive license by HVMN Inc.

H.V.M.N.
38 Mason St, 3rd Floor, San Francisco, CA 94102
Email us: care@hvmn.com

These statements have not been evaluated by the FDA. Our products are not intended to diagnose, treat, cure, or prevent any disease.

© 2020 HVMN Inc. All Rights Reserved. H.V.M.N.®, Health Via Modern Nutrition™, Nootrobox®, Rise™, Sprint®, Yawn®, Kado™, and GO Cubes® are registered trademarks of HVMN Inc. ΔG® is a trademark of TΔS® and used under exclusive license by HVMN Inc.